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Compound Detail

CHEMBL5785658

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COc1cc(OCC2CCN(C)CC2)ccc1-c1cc(Nc2cnc(C#N)cn2)n[nH]1

Basic Information

ChEMBL ID CHEMBL5785658
Phase Preclinical
Structure Type MOL
InChI Key XOMSEQMGFZDXTN-UHFFFAOYSA-N
1
Targets
3
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

419.5
MW (Da)
3.21
ALogP
8
HBA
2
HBD
112.0
PSA (Ų)
0.60
QED
0
Ro5 Violations
7
Rot. Bonds

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C22H25N7O2
MW 419.49
Aromatic Rings 3
Heavy Atoms 31
NP-Likeness -1.09

Activity Summary

IC50 3 meas. best 10.17

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Serine/threonine-protein kinase Chk1
CHEMBL4630
IC50 10.17 9.97 0.1 3

Activity Data Samples

Top measurements by pChEMBL value

Data from ChEMBL 36 via Core Engine