Compound Detail
CHEMBL5787737
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Cc1nn(Cc2ccccc2)c(C)c1C(=O)N1CCC2(CC1)CC2CNC(=O)c1cc2ccncc2o1
Basic Information
| ChEMBL ID | CHEMBL5787737 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VSBKDIKZVRWAOH-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
497.6
MW (Da)
4.36
ALogP
6
HBA
1
HBD
93.3
PSA (Ų)
0.43
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.84
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Nicotinamide phosphoribosyltransferase CHEMBL1744525 | IC50 | 7.84 | 7.84 | 14.5 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Nicotinamide phosphoribosyltransferase | IC50 | = | 14.5 | nM | 7.84 | Biochemical Inhibition Assay: The NAMPT enzymatic reactions were carried out in ... | - |
Data from ChEMBL 36 via Core Engine