Compound Detail
CHEMBL5790611
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Basic Information
| ChEMBL ID | CHEMBL5790611 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | IQJHHPMHEXAHQP-UHFFFAOYSA-N |
1
Targets
4
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
455.5
MW (Da)
4.36
ALogP
7
HBA
1
HBD
95.5
PSA (Ų)
0.49
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 9.52
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Diacylglycerol O-acyltransferase 1 CHEMBL6009 | IC50 | 9.52 | 9.1275 | 0.3 | 4 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Diacylglycerol O-acyltransferase 1 | IC50 | = | 0.3 | nM | 9.52 | Human DGAT1LE Assay: For inhibition of triacylglycerol product formation, 11 uL ... | - |
| Diacylglycerol O-acyltransferase 1 | IC50 | = | 0.3 | nM | 9.52 | LE Assay: For inhibition of triacylglycerol product formation, 11 uL reactions w... | - |
| Diacylglycerol O-acyltransferase 1 | IC50 | = | 0.3 | nM | 9.52 | Lipid Extraction (LE) Assay: For inhibition of triacylglycerol product formation... | - |
| Diacylglycerol O-acyltransferase 1 | IC50 | = | 11.2 | nM | 7.95 | Lipid Extraction (LE) Assay: For inhibition of triacylglycerol product formation... | - |
Data from ChEMBL 36 via Core Engine