Compound Detail
CHEMBL579196
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Basic Information
| ChEMBL ID | CHEMBL579196 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MLCNCVBBXLTIHF-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
457.8
MW (Da)
7.40
ALogP
4
HBA
0
HBD
35.6
PSA (Ų)
0.32
QED
1
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 8.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Cannabinoid receptor 1 CHEMBL218 | Ki | 8.3 | 8.3 | 5.0 | 1 |
| Cannabinoid receptor 1 CHEMBL3571 | Ki | 8.0 | 8.0 | 10.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Cannabinoid receptor 1 | Ki | = | 5.0 | nM | 8.3 | Antagonist activity at human CB1 receptor transfected in CHO-K1cells by GTPgamma... | 19683918 |
| Cannabinoid receptor 1 | Ki | = | 10.0 | nM | 8.0 | Displacement of [3H]SR141716A from rat brain CB1 receptor | 19683918 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19683918 | 10.1016/j.bmcl.2009.07.130 | Cannabinoid receptor 1 | 2 |
| 19683918 | 10.1016/j.bmcl.2009.07.130 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine