Compound Detail
CHEMBL579217
FLORBENAZINE 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL579217 |
| Name | FLORBENAZINE |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | GNKGXQHHUUEYQV-BHIYHBOVSA-N |
2
Targets
4
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
365.5
MW (Da)
3.76
ALogP
4
HBA
1
HBD
41.9
PSA (Ų)
0.75
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Single Enantiomer |
Activity Summary
Ki 4 meas. best 10.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Synaptic vesicular amine transporter CHEMBL1893 | Ki | 10.0 | 10.0 | 0.1 | 1 |
| Synaptic vesicular amine transporter CHEMBL4828 | Ki | 10.0 | 9.6867 | 0.1 | 3 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Synaptic vesicular amine transporter | Ki | = | 0.1 | nM | 10.0 | Binding affinity to VMAT2 | 19632829 |
| Synaptic vesicular amine transporter | Ki | = | 0.1 | nM | 10.0 | Displacement of [125I]-iodovinyl-TBZ from VMAT2 in rat striatal homogenate after... | 21531556 |
| Synaptic vesicular amine transporter | Ki | = | 0.24 | nM | 9.62 | Displacement of [125I]-iodovinyl-TBZ from VMAT2 in rat striatal membrane homogen... | 19632829 |
| Synaptic vesicular amine transporter | Ki | = | 0.36 | nM | 9.44 | Displacement of [3H]-DTBZ from VMAT2 in rat striatal membrane homogenates | 19632829 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19632829 | 10.1016/j.bmcl.2009.07.048 | Synaptic vesicular amine transporter | 3 |
| 19632829 | 10.1016/j.bmcl.2009.07.048 | ADMET | 1 |
| 21531556 | 10.1016/j.bmcl.2011.03.113 | Synaptic vesicular amine transporter | 1 |
Data from ChEMBL 36 via Core Engine