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Compound Detail

CHEMBL5795338

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COC(=O)c1cccc(N2CCC3(CCC(=O)NC3=O)C2)n1
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL5795338
Phase Preclinical
Structure Type MOL
InChI Key CLLLSNBLTMBAMO-UHFFFAOYSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

303.3
MW (Da)
0.50
ALogP
6
HBA
1
HBD
88.6
PSA (Ų)
0.63
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C15H17N3O4
MW 303.32
Aromatic Rings 1
Heavy Atoms 22
NP-Likeness -0.80

Activity Summary

Kd 1 meas. best 9.0

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Protein cereblon
CHEMBL3763008
 Kd 9.0 9.0 1.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Protein cereblon Kd = 1.0 nM 9.0 Fluorescence Direct Binding Asaay: Determination of the affinities of compounds ... -

Data from ChEMBL 36 via Core Engine