Compound Detail
CHEMBL5802087
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CN1CCC(Oc2nc(-c3ccc(NS(=O)(=O)c4cc(Cl)ccc4F)cc3)nc3[nH]ncc23)CC1
Basic Information
| ChEMBL ID | CHEMBL5802087 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | BMTHVZMGMOJKRU-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
517.0
MW (Da)
4.09
ALogP
7
HBA
2
HBD
113.1
PSA (Ų)
0.40
QED
1
Ro5 Violations
6
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 9.23
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Serine/threonine-protein kinase Sgk1 CHEMBL2343 | IC50 | 9.23 | 9.23 | 0.6 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Serine/threonine-protein kinase Sgk1 | IC50 | = | 0.59 | nM | 9.23 | Enzymatic Activity Assay: The compounds were tested for serum and glucocorticoid... | - |
Data from ChEMBL 36 via Core Engine