Compound Detail
CHEMBL581906
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Basic Information
| ChEMBL ID | CHEMBL581906 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | PDYLKRWZXXTAQJ-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
7
Publications
0
Known Names
Molecular Properties
264.7
MW (Da)
1.37
ALogP
3
HBA
1
HBD
49.4
PSA (Ų)
0.88
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 4.69
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate receptor 2 CHEMBL4016 | EC50 | 4.69 | 4.69 | 20400.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate receptor 2 | EC50 | = | 20417.38 | nM | 4.69 | Positive allosteric modulation of GluA2 (Q) flop isoform (unknown origin) expres... | 29256599 |
| Glutamate receptor 2 | EC50 | = | 20400.0 | nM | 4.69 | Positive allosteric modulation of GluA2 (Q) flop isoform (unknown origin) expres... | 29256599 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 20108934 | 10.1021/jm901495t | Rattus norvegicus | 6 |
| 20108934 | 10.1021/jm901495t | Hippocampus | 4 |
| 20108934 | 10.1021/jm901495t | Oocyte | 2 |
| 29256599 | 10.1021/acs.jmedchem.7b01323 | Glutamate receptor 2 | 2 |
| 20108934 | 10.1021/jm901495t | No relevant target | 1 |
| 20108934 | 10.1021/jm901495t | Liver microsomes | 1 |
| 29256599 | 10.1021/acs.jmedchem.7b01323 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine