Compound Detail
CHEMBL5834831
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CC1Cc2nc3c(c(-c4cc(C(N)=O)c(O)c5c4OCO5)cn3CC(=O)Nc3cc(N4CCN(C)C[C@@H]4C)nc(F)c3Cl)c(=O)n2C1
Basic Information
| ChEMBL ID | CHEMBL5834831 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FNWFEDVOSBNILU-LOACHALJSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
667.1
MW (Da)
2.56
ALogP
12
HBA
3
HBD
170.1
PSA (Ų)
0.26
QED
2
Ro5 Violations
6
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Kd 1 meas. best 9.11
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| BCL-6/NCOR2 CHEMBL4523673 | Kd | 9.11 | 9.11 | 0.8 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| BCL-6/NCOR2 | Kd | = | 0.77 | nM | 9.11 | BCL6-BTB-SMRT Peptide Inhibition Fluorescence Polarization (FP) Screen: This ass... | - |
Data from ChEMBL 36 via Core Engine