Compound Detail
CHEMBL5836045
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Basic Information
| ChEMBL ID | CHEMBL5836045 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UHSDZFMWCROEFN-UHFFFAOYSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
422.9
MW (Da)
4.42
ALogP
7
HBA
2
HBD
96.7
PSA (Ų)
0.43
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 8.4
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform CHEMBL3130 | IC50 | 8.4 | 7.24 | 4.0 | 2 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform CHEMBL3267 | IC50 | 5.59 | 5.59 | 2593.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | IC50 | = | 4.0 | nM | 8.4 | Transcreener KINASE Assay: Briefly, the Transcreener KINASE Assay was designed a... | - |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | IC50 | = | 839.0 | nM | 6.08 | Transcreener KINASE Assay: Briefly, the Transcreener KINASE Assay was designed a... | - |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | IC50 | = | 2593.0 | nM | 5.59 | Transcreener KINASE Assay: Briefly, the Transcreener KINASE Assay was designed a... | - |
Data from ChEMBL 36 via Core Engine