Compound Detail
CHEMBL583892
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL583892 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MQNCXPOMDAPQOF-SXGWCWSVSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
450.3
MW (Da)
4.62
ALogP
6
HBA
0
HBD
76.8
PSA (Ų)
0.49
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 4.73
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Integrin alpha-M/beta-2 CHEMBL2111362 | EC50 | 4.73 | 4.73 | 18600.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Integrin alpha-M/beta-2 | EC50 | = | 18600.0 | nM | 4.73 | Agonist activity at CD11b/CD18 expressed in K562 cells assessed as increase in c... | 19879752 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 27626828 | 10.1021/acs.jmedchem.6b01058 | Excitatory amino acid transporter 1 | 2 |
| 19879752 | 10.1016/j.bmcl.2009.10.077 | Integrin alpha-M/beta-2 | 1 |
| 27626828 | 10.1021/acs.jmedchem.6b01058 | Excitatory amino acid transporter 3 | 1 |
| 27626828 | 10.1021/acs.jmedchem.6b01058 | Excitatory amino acid transporter 2 | 1 |
Data from ChEMBL 36 via Core Engine