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Compound Detail

CHEMBL5844919

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COc1ccc(CN(Cc2ccc(OC)cc2)c2cc([C@H](C)N[S+]([O-])C(C)(C)C)c(-c3ccccc3C)nn2)cc1

Basic Information

ChEMBL ID CHEMBL5844919
Phase Preclinical
Structure Type MOL
InChI Key WLDAFMKORBHDLI-JDRJKRQWSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

572.8
MW (Da)
6.79
ALogP
7
HBA
1
HBD
82.6
PSA (Ų)
0.20
QED
2
Ro5 Violations
11
Rot. Bonds

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C33H40N4O3S
MW 572.78
Aromatic Rings 4
Heavy Atoms 41
NP-Likeness -0.66

Activity Summary

IC50 3 meas. best 8.4

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
CHEMBL3130
IC50 8.4 8.4 4.0 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
CHEMBL3267
IC50 6.84 6.84 146.0 1
Phosphatidylinositol 3-kinase regulatory subunit beta
CHEMBL4437
IC50 6.43 6.43 371.0 1

Activity Data Samples

Top measurements by pChEMBL value

Data from ChEMBL 36 via Core Engine