Compound Detail
CHEMBL5869878
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
COc1ccc(C[C@@H]2NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]3CCCC/C=C\CCCC[C@H](NC(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)CCSCc4cccc(c4)CSCCNC(=O)[C@]4(C)CCCN4C2=O)C(=O)N[C@@H](Cc2c[nH]c4ccc(F)cc24)C(=O)N3)cc1
Basic Information
| ChEMBL ID | CHEMBL5869878 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LCYSOOPHKDMGSN-FMLKXECWSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
1253.6
MW (Da)
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| PCSK9/LDLR CHEMBL4523996 | IC50 | 7.3 | 6.78 | 50.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| PCSK9/LDLR | IC50 | = | 50.0 | nM | 7.3 | Alexa Fret: The PCSK9 Alexa FRET Standard assay measured the interaction between... | - |
| PCSK9/LDLR | IC50 | = | 550.0 | nM | 6.26 | Identification of Polypeptides that Bind Specifically to Human PCSK9 and Inhibit... | - |
Data from ChEMBL 36 via Core Engine