Compound Detail
CHEMBL5875026
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Basic Information
| ChEMBL ID | CHEMBL5875026 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HDRZADSWJHVRRT-NVXWUHKLSA-N |
1
Targets
3
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
443.5
MW (Da)
2.87
ALogP
9
HBA
2
HBD
105.2
PSA (Ų)
0.55
QED
0
Ro5 Violations
8
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 7.57
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutaminase kidney isoform, mitochondrial CHEMBL2146302 | IC50 | 7.57 | 7.0367 | 27.0 | 3 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutaminase kidney isoform, mitochondrial | IC50 | = | 27.0 | nM | 7.57 | GLS Enzyme Potency Assay: A Glutamate Oxidase/AmplexRed coupled assay was used t... | - |
| Glutaminase kidney isoform, mitochondrial | IC50 | = | 170.0 | nM | 6.77 | GLS Enzyme Potency Assay: A Glutamate Oxidase/AmplexRed coupled assay was used t... | - |
| Glutaminase kidney isoform, mitochondrial | IC50 | = | 170.0 | nM | 6.77 | GLS Enzyme Potency Assay: A Glutamate Oxidase/AmplexRed coupled assay was used t... | - |
Data from ChEMBL 36 via Core Engine