Compound Detail
CHEMBL5898151
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Basic Information
| ChEMBL ID | CHEMBL5898151 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UDPYQPXRZTYCGV-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
333.4
MW (Da)
3.46
ALogP
6
HBA
2
HBD
98.3
PSA (Ų)
0.59
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.64
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Proto-oncogene tyrosine-protein kinase receptor Ret CHEMBL2041 | IC50 | 7.64 | 7.64 | 23.1 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Proto-oncogene tyrosine-protein kinase receptor Ret | IC50 | = | 23.1 | nM | 7.64 | Time-Resolved Fluorescence Transfer (FRET) Assay: RET and KDR: Kinase activity w... | - |
| Proto-oncogene tyrosine-protein kinase receptor Ret | IC50 | = | 23.1 | nM | 7.64 | RET and KDR Enzyme Assay: Kinase activity was detected using CisBio HTRF kinEASE... | - |
Data from ChEMBL 36 via Core Engine