Compound Detail
CHEMBL5914310
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL5914310 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ZXSMJBMMAAHHKL-AEFFLSMTSA-N |
1
Targets
4
Activities
2
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
402.4
MW (Da)
2.57
ALogP
5
HBA
1
HBD
76.5
PSA (Ų)
0.73
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.3
Ki 2 meas. best 8.05
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Receptor-interacting serine/threonine-protein kinase 1 CHEMBL5464 | Ki | 8.05 | 7.8 | 9.0 | 2 |
| Receptor-interacting serine/threonine-protein kinase 1 CHEMBL5464 | IC50 | 6.3 | 6.3 | 500.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Receptor-interacting serine/threonine-protein kinase 1 | Ki | = | 9.0 | nM | 8.05 | Enzyme Assay: The ability of the receptor interacting protein kinase (RIPK1) to ... | - |
| Receptor-interacting serine/threonine-protein kinase 1 | Ki | = | 28.0 | nM | 7.55 | Enzyme Assay: The ability of the receptor interacting protein kinase (RIPK1) to ... | - |
| Receptor-interacting serine/threonine-protein kinase 1 | IC50 | = | 500.0 | nM | 6.3 | Fluorescent Polarization Binding (FP Binding) assay: Assay was performed in poly... | - |
| Receptor-interacting serine/threonine-protein kinase 1 | IC50 | = | 500.0 | nM | 6.3 | Fluorescent Polarization Binding (FP Binding) assay: Test compounds were diluted... | - |
Data from ChEMBL 36 via Core Engine