Compound Detail
CHEMBL5914638
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Basic Information
| ChEMBL ID | CHEMBL5914638 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UWEGPARKXFKMJU-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
440.5
MW (Da)
2.44
ALogP
7
HBA
2
HBD
117.1
PSA (Ų)
0.35
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.63
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Histone deacetylase 8 CHEMBL3192 | IC50 | 6.63 | 6.63 | 235.0 | 1 |
| Histone deacetylase 6 CHEMBL1865 | IC50 | 5.35 | 5.35 | 4450.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Histone deacetylase 8 | IC50 | = | 235.0 | nM | 6.63 | Enzymatic Assay: The IC50 values for aforementioned compounds against HDACs were... | - |
| Histone deacetylase 6 | IC50 | = | 4450.0 | nM | 5.35 | Enzymatic Assay: The IC50 values for aforementioned compounds against HDACs were... | - |
Data from ChEMBL 36 via Core Engine