Compound Detail
CHEMBL5920986
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Basic Information
| ChEMBL ID | CHEMBL5920986 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | IHRBYCRDSUMVII-CHWSQXEVSA-N |
2
Targets
6
Activities
2
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
389.4
MW (Da)
2.84
ALogP
5
HBA
1
HBD
63.7
PSA (Ų)
0.81
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 7.5
EC50 2 meas. best 8.4
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Somatostatin receptor type 4 CHEMBL1853 | EC50 | 8.4 | 7.6 | 4.0 | 2 |
| Somatostatin receptor type 4 CHEMBL1853 | IC50 | 7.5 | 6.8 | 31.6 | 2 |
| Somatostatin receptor type 1 CHEMBL1917 | IC50 | 5.3 | 5.0 | 5012.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Somatostatin receptor type 4 | EC50 | = | 3.98 | nM | 8.4 | Inhibition of Forskolin Stimulated cAMP in Cells Overexpressing SSTR4: This cell... | - |
| Somatostatin receptor type 4 | IC50 | = | 31.6 | nM | 7.5 | SSTR4 I-125 Somatostatin Competition Binding Assay: This membrane-based assay me... | - |
| Somatostatin receptor type 4 | EC50 | = | 158.0 | nM | 6.8 | Inhibition of Forskolin Stimulated cAMP in Cells Overexpressing SSTR4: This cell... | - |
| Somatostatin receptor type 4 | IC50 | = | 794.0 | nM | 6.1 | SSTR4 I-125 Somatostatin Competition Binding Assay: This membrane-based assay me... | - |
| Somatostatin receptor type 1 | IC50 | = | 5012.0 | nM | 5.3 | SSTR1 I-125 Somatostatin Competition Binding Assay for Selectivity Versus SSTR4:... | - |
| Somatostatin receptor type 1 | IC50 | = | 19953.0 | nM | 4.7 | SSTR1 I-125 Somatostatin Competition Binding Assay for Selectivity Versus SSTR4:... | - |
Data from ChEMBL 36 via Core Engine