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Compound Detail

CHEMBL5924382

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O=C1CCC2(CCN(c3nc4ccccc4s3)C2)C(=O)N1

Basic Information

ChEMBL ID CHEMBL5924382
Phase Preclinical
Structure Type MOL
InChI Key YVQKTFGXZGHQOQ-UHFFFAOYSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

301.4
MW (Da)
1.93
ALogP
5
HBA
1
HBD
62.3
PSA (Ų)
0.82
QED
0
Ro5 Violations
1
Rot. Bonds

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C15H15N3O2S
MW 301.37
Aromatic Rings 2
Heavy Atoms 21
NP-Likeness -1.34

Activity Summary

Kd 1 meas. best 9.0

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Protein cereblon
CHEMBL3763008
Kd 9.0 9.0 1.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Protein cereblon Kd = 1.0 nM 9.0 Fluorescence Direct Binding Asaay: Determination of the affinities of compounds ... -

Data from ChEMBL 36 via Core Engine