Compound Detail
CHEMBL594062
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CS(=O)(=O)c1cccc(Oc2cccc(-n3c(Cc4ccc(F)cc4)nc4c(C(F)(F)F)cccc43)c2)c1
Basic Information
| ChEMBL ID | CHEMBL594062 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MFDLTITVUNIPCT-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
3
PK Parameters
7
Publications
0
Known Names
Molecular Properties
540.5
MW (Da)
6.97
ALogP
5
HBA
0
HBD
61.2
PSA (Ų)
0.22
QED
2
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 8.92
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Oxysterols receptor LXR-alpha CHEMBL2808 | IC50 | 8.92 | 8.92 | 1.2 | 1 |
| Oxysterols receptor LXR-beta CHEMBL4093 | IC50 | 8.59 | 8.59 | 2.6 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| T1/2 | 0.1333 | hr | Mus musculus |
| T1/2 | 0.5 | hr | Rattus norvegicus |
| T1/2 | 0.3833 | hr | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Oxysterols receptor LXR-alpha | IC50 | = | 1.2 | nM | 8.92 | Displacement of [3H]T0901317 from human recombinant LXRalpha LBD | 20006495 |
| Oxysterols receptor LXR-beta | IC50 | = | 2.6 | nM | 8.59 | Displacement of [3H]T0901317 from human recombinant LXRbeta LBD | 20006495 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 20006495 | 10.1016/j.bmcl.2009.11.099 | Liver microsomes | 2 |
| 20006495 | 10.1016/j.bmcl.2009.11.099 | Oxysterols receptor LXR-alpha | 1 |
| 20006495 | 10.1016/j.bmcl.2009.11.099 | Oxysterols receptor LXR-beta | 1 |
| 20006495 | 10.1016/j.bmcl.2009.11.099 | Liver X receptor (LXR alpha AND LXR beta) | 1 |
| 20006495 | 10.1016/j.bmcl.2009.11.099 | THP-1 | 1 |
| 20006495 | 10.1016/j.bmcl.2009.11.099 | HepG2 | 1 |
| 20006495 | 10.1016/j.bmcl.2009.11.099 | ADMET | 1 |
Data from ChEMBL 36 via Core Engine