Compound Detail
CHEMBL5946796
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Basic Information
| ChEMBL ID | CHEMBL5946796 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UMYYXVFNOILWEP-DCXKMBIZSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
419.3
MW (Da)
3.90
ALogP
6
HBA
2
HBD
107.1
PSA (Ų)
0.73
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.63
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Endothelial PAS domain-containing protein 1 CHEMBL1744522 | IC50 | 7.63 | 7.615 | 23.2 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Endothelial PAS domain-containing protein 1 | IC50 | = | 23.2 | nM | 7.63 | Scintillation Proximity Assay (SPA): HIF-2a: The total assay volume was about 10... | - |
| Endothelial PAS domain-containing protein 1 | IC50 | = | 25.0 | nM | 7.6 | Scintillation Proximity Assay (SPA): HIF-2a: The total assay volume was about 10... | - |
Data from ChEMBL 36 via Core Engine