Compound Detail
CHEMBL5964364
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Basic Information
| ChEMBL ID | CHEMBL5964364 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KJFZIUZDYNNQKR-UHFFFAOYSA-N |
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
380.4
MW (Da)
2.78
ALogP
6
HBA
1
HBD
80.0
PSA (Ų)
0.75
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Kd 4 meas. best 7.16
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform CHEMBL3130 | Kd | 7.16 | 7.16 | 69.0 | 1 |
| Unchecked CHEMBL612545 | Kd | 5.97 | 5.97 | 1072.0 | 1 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform CHEMBL3267 | Kd | 5.21 | 5.21 | 6166.0 | 1 |
| Serine/threonine-protein kinase mTOR CHEMBL2842 | Kd | 5.03 | 5.03 | 9333.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | Kd | = | 69.0 | nM | 7.16 | KINOMEscan Enzyme Binding Assays: Kinase enzyme binding affinities of compounds ... | - |
| Unchecked | Kd | = | 1072.0 | nM | 5.97 | KINOMEscan Enzyme Binding Assays: Kinase enzyme binding affinities of compounds ... | - |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | Kd | = | 6166.0 | nM | 5.21 | KINOMEscan Enzyme Binding Assays: Kinase enzyme binding affinities of compounds ... | - |
| Serine/threonine-protein kinase mTOR | Kd | = | 9333.0 | nM | 5.03 | KINOMEscan Enzyme Binding Assays: Kinase enzyme binding affinities of compounds ... | - |
Data from ChEMBL 36 via Core Engine