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Compound Detail

CHEMBL5985840

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CC(C)(c1cccc(Cl)c1)N1CCC[C@@H](Oc2cc(F)c(C(N)=O)cc2C2CC2)C1

Basic Information

ChEMBL ID CHEMBL5985840
Phase Preclinical
Structure Type MOL
InChI Key WGJKXBIAQQOYRR-GOSISDBHSA-N
1
Targets
4
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

430.9
MW (Da)
5.23
ALogP
3
HBA
1
HBD
55.6
PSA (Ų)
0.68
QED
1
Ro5 Violations
6
Rot. Bonds

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C24H28ClFN2O2
MW 430.95
Aromatic Rings 2
Heavy Atoms 30
NP-Likeness -0.87

Activity Summary

IC50 4 meas. best 8.64

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
IC50 8.64 8.63 2.3 4

Activity Data Samples

Top measurements by pChEMBL value

Data from ChEMBL 36 via Core Engine