Compound Detail
CHEMBL5988720
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Basic Information
| ChEMBL ID | CHEMBL5988720 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MNIDEEVBVHGHCD-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
459.5
MW (Da)
3.46
ALogP
4
HBA
1
HBD
78.4
PSA (Ų)
0.76
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.9
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Nicotinamide phosphoribosyltransferase CHEMBL1744525 | IC50 | 7.9 | 7.9 | 12.5 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Nicotinamide phosphoribosyltransferase | IC50 | = | 12.5 | nM | 7.9 | Biochemical Inhibition Assay: NAMPT Protein Purification. Recombinant His-tagged... | - |
| Nicotinamide phosphoribosyltransferase | IC50 | = | 12.5 | nM | 7.9 | Biochemical Inhibition Assay: The NAMPT enzymatic reactions were carried out in ... | - |
Data from ChEMBL 36 via Core Engine