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Compound Detail

CHEMBL5997384

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COc1ccc(C(F)(F)C(=O)N[C@@H](Cc2coc3ccccc23)B(O)O)cc1

Basic Information

ChEMBL ID CHEMBL5997384
Phase Preclinical
Structure Type MOL
InChI Key DZNFKFLIBIWWML-KRWDZBQOSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

389.2
MW (Da)

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C19H18BF2NO5
MW 389.16

Activity Summary

IC50 1 meas. best 5.56

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Proteasome Macropain subunit MB1
CHEMBL4662
IC50 5.56 5.56 2750.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Proteasome Macropain subunit MB1 IC50 = 2750.0 nM 5.56 Determination of Beta5 Activity: Measurement of Beta5 inhibition is performed in... -

Data from ChEMBL 36 via Core Engine