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Compound Detail

CHEMBL5997734

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Cc1nnc(NC(=O)c2cc([C@H]3C[C@@H]3NC3CCC3)cs2)s1
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL5997734
Phase Preclinical
Structure Type MOL
InChI Key ALKUEFQXLXYBPP-NEPJUHHUSA-N
2
Targets
11
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

334.5
MW (Da)
3.16
ALogP
6
HBA
2
HBD
66.9
PSA (Ų)
0.88
QED
0
Ro5 Violations
5
Rot. Bonds

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C15H18N4OS2
MW 334.47
Aromatic Rings 2
Heavy Atoms 22
NP-Likeness -1.93

Activity Summary

IC50 11 meas. best 6.72

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
 IC50 6.72 6.51 190.0 5
Lysine-specific histone demethylase 1A
CHEMBL6136
 IC50 6.09 6.09 810.0 6

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Unchecked IC50 = 190.0 nM 6.72 Inhibitory Activity Assay: A test compound dissolved in DMSO was added by to a r... -
Unchecked IC50 = 240.0 nM 6.62 Inhibitory Activity Assay: A test compound dissolved in DMSO was added by to a r... -
Unchecked IC50 = 260.0 nM 6.58 Inhibitory Activity Assay: A test compound dissolved in DMSO was added by to a r... -
Unchecked IC50 = 290.0 nM 6.54 Inhibitory Activity Assay: A test compound dissolved in DMSO was added by to a r... -
Unchecked IC50 = 810.0 nM 6.09 Inhibitory Activity Assay: A test compound dissolved in DMSO was added by to a r... -
Lysine-specific histone demethylase 1A IC50 = 810.0 nM 6.09 LSD1 Inhibitory Activity: A test compound dissolved in DMSO was added by to a re... -
Lysine-specific histone demethylase 1A IC50 = 810.0 nM 6.09 LSD1 Inhibitory Assay: A test compound dissolved in DMSO was added by to a react... -
Lysine-specific histone demethylase 1A IC50 = 810.0 nM 6.09 LSD1 Inhibitory Assay: A test compound dissolved in DMSO was added by to a react... -
Lysine-specific histone demethylase 1A IC50 = 810.0 nM 6.09 Inhibition Assay: A test compound dissolved in DMSO was added by to a reaction s... -
Lysine-specific histone demethylase 1A IC50 = 810.0 nM 6.09 Inhibition Activity Assay: LSD1: A test compound dissolved in DMSO was added by ... -
Lysine-specific histone demethylase 1A IC50 = 810.0 nM 6.09 Inhibitory Activity Assay: LSD1: A test compound dissolved in DMSO was added by ... -

Data from ChEMBL 36 via Core Engine