Compound Detail
CHEMBL5997844
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Basic Information
| ChEMBL ID | CHEMBL5997844 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GWOCNAQGMAATMQ-IRLDBZIGSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
411.5
MW (Da)
5.58
ALogP
5
HBA
0
HBD
57.1
PSA (Ų)
0.40
QED
1
Ro5 Violations
7
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 10.4
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A CHEMBL4409 | Ki | 10.4 | 9.345 | 0.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | Ki | = | 0.04 | nM | 10.4 | Fluorescence Polarization Assay: The fluorescence polarization assay for cyclic ... | - |
| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | Ki | = | 5.08 | nM | 8.29 | Fluorescence Polarization Assay: The fluorescence polarization assay for cyclic ... | - |
Data from ChEMBL 36 via Core Engine