Compound Detail
CHEMBL6017060
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Cc1ccc(-c2ccnc3[nH]c(-c4n[nH]c5ccc(-c6cncc(NC(=O)C(C)(C)C)c6)cc45)nc23)s1
Basic Information
| ChEMBL ID | CHEMBL6017060 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HMRALHODFLHHIT-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
507.6
MW (Da)
6.58
ALogP
6
HBA
3
HBD
112.2
PSA (Ų)
0.25
QED
2
Ro5 Violations
4
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 9.22
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Proto-oncogene Wnt-1 CHEMBL1255129 | IC50 | 9.22 | 9.22 | 0.6 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Proto-oncogene Wnt-1 | IC50 | = | 0.6 | nM | 9.22 | The screening assay for Wnt activity: Reporter cell lines can be generated by st... | - |
Data from ChEMBL 36 via Core Engine