Compound Detail
CHEMBL6019845
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Basic Information
| ChEMBL ID | CHEMBL6019845 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QKSGURGYBJINNR-HIFRSBDPSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
442.5
MW (Da)
1.75
ALogP
11
HBA
2
HBD
127.3
PSA (Ų)
0.53
QED
1
Ro5 Violations
8
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.45
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutaminase kidney isoform, mitochondrial CHEMBL2146302 | IC50 | 7.45 | 7.45 | 35.5 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutaminase kidney isoform, mitochondrial | IC50 | = | 35.5 | nM | 7.45 | GLS Enzyme Potency Assay: A Glutamate Oxidase/AmplexRed coupled assay was used t... | - |
| Glutaminase kidney isoform, mitochondrial | IC50 | = | 35.5 | nM | 7.45 | GLS Enzyme Potency Assay: A Glutamate Oxidase/AmplexRed coupled assay was used t... | - |
Data from ChEMBL 36 via Core Engine