Compound Detail

CHEMBL6038884

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COc1c(C(C)n2nc(C)c3c(N)nccc32)cc(Cl)c(C)c1-c1ccc(C(=O)N(C)C)nc1

ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID	CHEMBL6038884
Phase	Preclinical
Structure Type	MOL
InChI Key	MRVLFHBXSHLHOL-UHFFFAOYSA-N

Targets

Activities

Assay Types

PK Parameters

Publications

Known Names

479.0

MW (Da)

4.67

ALogP

HBA

HBD

99.2

PSA (Å²)

0.45

QED

Ro5 Violations

Rot. Bonds

Availability	Unknown
Chirality	Unknown

First in Class Prodrug

IC50 6 meas. best 6.9

Target	Type	Best pChEMBL	Mean pChEMBL	Best (nM)	# Data
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform CHEMBL3130	IC50	6.9	6.9	125.0	6

Top measurements by pChEMBL value

Target	Type	Rel.	Value	Units	pChEMBL	Assay	PubMed
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IC50	=	125.0	nM	6.9	PI3K delta Scintillation Proximity Assay: [γ-33P]ATP (10 mCi/mL) was purchased f...	-
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IC50	=	125.0	nM	6.9	Scintillation Proximity Assay: [γ-33P]ATP (10 mCi/mL) was purchased from PerkinE...	-
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IC50	=	125.0	nM	6.9	Scintillation Proximity Assay: The kinase reaction was conducted in polystyrene ...	-
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IC50	=	125.0	nM	6.9	PI3Kdelta Scintillation Proximity A3 Assay: [γ-33P]ATP (10 mCi/mL) was purchased...	-
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IC50	=	125.0	nM	6.9	Scintillation Proximity Assay: The kinase reaction was conducted in polystyrene ...	-
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IC50	=	125.0	nM	6.9	PI3Kδ Scintillation Proximity Assay: The kinase reaction was conducted in polyst...	-

Data from ChEMBL 36 via Core Engine