Compound Detail
CHEMBL6044873
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Basic Information
| ChEMBL ID | CHEMBL6044873 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | XDEJIMDRAROROE-KYGLGHNPSA-N |
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
284.4
MW (Da)
0.50
ALogP
6
HBA
3
HBD
64.8
PSA (Ų)
0.69
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 6.46
Ki 1 meas. best 7.66
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Protein O-GlcNAcase CHEMBL5921 | Ki | 7.66 | 7.66 | 22.0 | 1 |
| Protein O-GlcNAcase CHEMBL5921 | EC50 | 6.46 | 6.46 | 349.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Protein O-GlcNAcase | Ki | = | 22.0 | nM | 7.66 | Fluorescence-based hOGA: Enzymatic reactions were carried out in a reaction cont... | - |
| Protein O-GlcNAcase | EC50 | = | 349.0 | nM | 6.46 | Cell-based ELISA: The ELISA portion of the assay is performed in a black Maxisor... | - |
Data from ChEMBL 36 via Core Engine