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Compound Detail

CHEMBL6057699

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CC(C)OC(=O)Nc1ccc(-c2cnc(C3CCc4cc(-c5cc(Cl)ccc5-n5cnnn5)cc(=O)n43)[nH]2)cc1

Basic Information

ChEMBL ID CHEMBL6057699
Phase Preclinical
Structure Type MOL
InChI Key NPVAKGTWUMBQTB-UHFFFAOYSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

557.0
MW (Da)
5.03
ALogP
9
HBA
2
HBD
132.6
PSA (Ų)
0.30
QED
2
Ro5 Violations
6
Rot. Bonds

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C28H25ClN8O3
MW 557.01
Aromatic Rings 5
Heavy Atoms 40
NP-Likeness -1.48

Activity Summary

IC50 1 meas. best 8.34

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Coagulation factor XI
CHEMBL2820
IC50 8.34 8.34 4.6 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Coagulation factor XI IC50 = 4.6 nM 8.34 Enzyme Activity Assay: Human Factor XIa (Haematologic Technologies Inc.) activit... -

Data from ChEMBL 36 via Core Engine