Compound Detail
CHEMBL6059110
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Basic Information
| ChEMBL ID | CHEMBL6059110 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | BFNZNEHBSBZTIV-UHFFFAOYSA-N |
1
Targets
4
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
384.9
MW (Da)
4.11
ALogP
6
HBA
2
HBD
94.6
PSA (Ų)
0.55
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 7.66
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Proto-oncogene tyrosine-protein kinase receptor Ret CHEMBL2041 | IC50 | 7.66 | 7.355 | 21.9 | 4 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Proto-oncogene tyrosine-protein kinase receptor Ret | IC50 | = | 21.9 | nM | 7.66 | Time-Resolved Fluorescence Transfer (FRET) Assay: RET and KDR: Kinase activity w... | - |
| Proto-oncogene tyrosine-protein kinase receptor Ret | IC50 | = | 21.9 | nM | 7.66 | RET and KDR Enzyme Assay: Kinase activity was detected using CisBio HTRF kinEASE... | - |
| Proto-oncogene tyrosine-protein kinase receptor Ret | IC50 | = | 88.7 | nM | 7.05 | Time-Resolved Fluorescence Transfer (FRET) Assay: RET and KDR: Kinase activity w... | - |
| Proto-oncogene tyrosine-protein kinase receptor Ret | IC50 | = | 88.7 | nM | 7.05 | RET and KDR Enzyme Assay: Kinase activity was detected using CisBio HTRF kinEASE... | - |
Data from ChEMBL 36 via Core Engine