Compound Detail
CHEMBL606394
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)c1cnccn1)B1OC2C[C@@H]3C[C@@H](C3(C)C)[C@]2(C)O1
Basic Information
| ChEMBL ID | CHEMBL606394 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HZCSTPSWJFWZHP-FXINVCJKSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
518.5
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 8.72
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Proteasome Macropain subunit MB1 CHEMBL4662 | IC50 | 8.72 | 8.72 | 1.9 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Proteasome Macropain subunit MB1 | IC50 | = | 1.92 | nM | 8.72 | Inhibition of chymotrypsin like activity of human 20S proteasome using Suc-Leu-L... | 27117691 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 27117691 | 10.1016/j.bmc.2016.04.025 | Proteasome Macropain subunit MB1 | 2 |
| 20131905 | 10.1021/jm9015685 | Proteasome component C5 | 1 |
| 20131905 | 10.1021/jm9015685 | Proteasome Macropain subunit MB1 | 1 |
Data from ChEMBL 36 via Core Engine