Compound Detail
CHEMBL606552
PAROMAMINE Enter ChEMBL ID:
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N[C@H]1[C@@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](N)C[C@@H]2N)O[C@H](CO)[C@@H](O)[C@@H]1O
Basic Information
| ChEMBL ID | CHEMBL606552 |
| Name | PAROMAMINE |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JGSMDVGTXBPWIM-HKEUSBCWSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
8
Publications
0
Known Names
Molecular Properties
323.4
MW (Da)
-5.08
ALogP
10
HBA
8
HBD
197.7
PSA (Ų)
0.25
QED
1
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.41
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | IC50 | 5.41 | 5.41 | 3900.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 3900.0 | nM | 5.41 | Binding affinity to decoding site rRNA of ribosome in Escherichia coli using Esc... | 27096052 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 24083676 | 10.1021/jm401148j | Staphylococcus aureus | 8 |
| 24083676 | 10.1021/jm401148j | Escherichia coli | 3 |
| 24083676 | 10.1021/jm401148j | Pseudomonas aeruginosa | 3 |
| 20409719 | 10.1016/j.bmc.2010.03.060 | Ribosome | 2 |
| 24083676 | 10.1021/jm401148j | Acinetobacter lwoffii | 2 |
| 11206440 | 10.1016/s0960-894x(00)00615-6 | Ribosomal RNA A-site | 1 |
| 24083676 | 10.1021/jm401148j | Klebsiella pneumoniae | 1 |
| 27096052 | 10.1021/acsmedchemlett.6b00006 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine