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Compound Detail

CHEMBL6067485

GENTAMICIN
💊 Approved Drug
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💊 Approved Drug
No structure available

Basic Information

ChEMBL ID CHEMBL6067485
Name GENTAMICIN
Phase Approved
Structure Type NONE
Therapeutic ✓ Yes

Known Names

Gentamicin Gentamicina Gentamicine Gentamycin Lyramycin Oksitselanim Septigen Uromycine
0
Targets
0
Activities
0
Assay Types
30
PK Parameters
0
Publications
8
Known Names
20
Indications

Drug Information

Molecule Type Small molecule
First Approval 1970
Availability Prescription
Chirality Single Enantiomer

Routes of Administration

Parenteral Topical

Flags

Black Box Warning
USAN Stem -micin
USAN Year 1963

Indications

Bacterial Infections Eye Infections Breast Neoplasms Cat-Scratch Disease Colonic Neoplasms Eczema Infections Kidney Calculi Pain Plague Premature Birth Rectal Neoplasms Sepsis Chorioamnionitis Cystic Fibrosis Diabetic Foot Folliculitis Leishmaniasis Leishmaniasis, Cutaneous Meniere Disease

ATC Classification

D06AX07
gentamicin
Level 1: DERMATOLOGICALS
Level 2: ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE
J01GB03
gentamicin
Level 1: ANTIINFECTIVES FOR SYSTEMIC USE
Level 2: ANTIBACTERIALS FOR SYSTEMIC USE
S01AA11
gentamicin
Level 1: SENSORY ORGANS
Level 2: OPHTHALMOLOGICALS
S02AA14
gentamicin
Level 1: SENSORY ORGANS
Level 2: OTOLOGICALS
S03AA06
gentamicin
Level 1: SENSORY ORGANS
Level 2: OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS

Pharmacokinetic Data

Parameter Value Units Species
AUC 63100.0 ng.hr.mL-1 -
AUC 70000.0 ng.hr.mL-1 Homo sapiens
AUC 70000.0 ng.hr.mL-1 Homo sapiens
AUC 135700.0 ng.hr.mL-1 Homo sapiens
AUC 88700.0 ng.hr.mL-1 Homo sapiens
CL 1.0 mL.min-1.kg-1 Homo sapiens
CL 0.3 mL.min-1.kg-1 Homo sapiens
CL 1.0 mL.min-1.kg-1 Homo sapiens
CL 1.0 mL.min-1.kg-1 Homo sapiens
CL 2.54 L/hr Homo sapiens
CL 0.23 L/hr Homo sapiens
Cmax 18.0 ug.mL-1 Homo sapiens
Cmax 4.0 ug.mL-1 Homo sapiens
Cmax 10.0 ug.mL-1 Homo sapiens
Cmax 15.8 ug.mL-1 -
Cmax 10.0 ug.mL-1 Homo sapiens
Cmax 10.0 ug.mL-1 Homo sapiens
Cmax 10.0 ug.mL-1 Homo sapiens
Cmax 10.0 ug.mL-1 Homo sapiens
Cmax 18.0 ug.mL-1 Homo sapiens
Fu 1.0 - Homo sapiens
Fu 1.0 - Homo sapiens
Fu 1.0 - Homo sapiens
MRT 5.5 hr Homo sapiens
T1/2 4.7 hr Homo sapiens
T1/2 0.85 hr Homo sapiens
T1/2 2.0 hr Homo sapiens
T1/2 3.4 hr -
T1/2 13.8 hr Homo sapiens
T1/2 153.4 hr Homo sapiens

Data from ChEMBL 36 via Core Engine