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Compound Detail

CHEMBL6068400

GIVINOSTAT HYDROCHLORIDE
💊 Approved Drug
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💊 Approved Drug
CCN(CC)Cc1ccc2cc(COC(=O)Nc3ccc(C(=O)NO)cc3)ccc2c1.Cl.O
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL6068400
Name GIVINOSTAT HYDROCHLORIDE
Phase Approved
Structure Type MOL
InChI Key FKGKZBBDJSKCIS-UHFFFAOYSA-N
Therapeutic ✓ Yes
Parent Compound CHEMBL1213492
Active Moiety CHEMBL1213492

Known Names

Duvyzat Givinostat hydrochloride ITF-2357 HYDROCHLORIDE MONOHYDRATE ITF2357 HYDROCHLORIDE ITF2357 HYDROCHLORIDE MONOHYDRATE
0
Targets
0
Activities
0
Assay Types
0
PK Parameters
0
Publications
5
Known Names
2
Indications
1
Mechanisms

Molecular Properties

421.5
MW (Da)
4.55
ALogP
5
HBA
3
HBD
90.9
PSA (Ų)
0.37
QED
0
Ro5 Violations
8
Rot. Bonds

Drug Information

Molecule Type Small molecule
First Approval 2024
Availability Prescription
Chirality Achiral

Routes of Administration

Oral

Flags

First in Class
USAN Stem -stat; -vin-
USAN Year 2023

Extended Properties

Molecular Formula C24H30ClN3O5
MW 475.97
Aromatic Rings 3
Heavy Atoms 31
NP-Likeness -1.10

Mechanism of Action

Mechanism Action Type Target Direct Efficacy
Histone deacetylase inhibitor INHIBITOR Histone deacetylase ✓ ✓

Indications

Muscular Dystrophy, Duchenne Polycythemia Vera

Data from ChEMBL 36 via Core Engine