Compound Detail
CHEMBL609289
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Basic Information
| ChEMBL ID | CHEMBL609289 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JWTHAIOFMVLSGZ-UHFFFAOYSA-N |
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
323.4
MW (Da)
1.29
ALogP
7
HBA
2
HBD
94.1
PSA (Ų)
0.88
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 6.22
Ki 1 meas. best 6.47
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Histamine H4 receptor CHEMBL3759 | Ki | 6.47 | 6.47 | 341.0 | 1 |
| Histamine H4 receptor CHEMBL3759 | EC50 | 6.22 | 6.22 | 602.6 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Histamine H4 receptor | Ki | = | 341.0 | nM | 6.47 | Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 ... | 19773175 |
| Histamine H4 receptor | EC50 | = | 602.56 | nM | 6.22 | Agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expres... | 19773175 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19773175 | 10.1016/j.bmc.2009.08.059 | Histamine H4 receptor | 3 |
Data from ChEMBL 36 via Core Engine