Compound Detail
CHEMBL609729
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Basic Information
| ChEMBL ID | CHEMBL609729 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | YDDPGVMQPXDRSI-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
257.7
MW (Da)
2.66
ALogP
4
HBA
2
HBD
81.2
PSA (Ų)
0.36
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 6.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Protein Tat CHEMBL4011 | EC50 | 6.0 | 6.0 | 1000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Protein Tat | EC50 | = | 1000.0 | nM | 6.0 | Inhibition of Tat-mediated transcription of viral promoter in 293 T cells transf... | 17444627 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17444627 | 10.1021/jm070014g | Protein Tat | 1 |
| 17444627 | 10.1021/jm070014g | Cyclin-dependent kinase inhibitor 1 | 1 |
Data from ChEMBL 36 via Core Engine