Compound Detail
CHEMBL609743
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Basic Information
| ChEMBL ID | CHEMBL609743 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JPZREZRJDYDZQS-OAHLLOKOSA-N |
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
389.9
MW (Da)
3.92
ALogP
3
HBA
3
HBD
74.0
PSA (Ų)
0.62
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 8.35
Ki 1 meas. best 8.52
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 6 CHEMBL3371 | Ki | 8.52 | 8.52 | 3.0 | 1 |
| 5-hydroxytryptamine receptor 6 CHEMBL3371 | EC50 | 8.35 | 8.35 | 4.5 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 6 | Ki | = | 3.0 | nM | 8.52 | Inhibition of [3H]LSD binding to human 5-hydroxytryptamine 6 receptor expressed ... | 15658848 |
| 5-hydroxytryptamine receptor 6 | EC50 | = | 4.5 | nM | 8.35 | Effective agonist concentration in cAMP release assay in HeLa cells expressing h... | 15658848 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15658848 | 10.1021/jm049243i | 5-hydroxytryptamine receptor 6 | 3 |
Data from ChEMBL 36 via Core Engine