Compound Detail
CHEMBL62086
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Basic Information
| ChEMBL ID | CHEMBL62086 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RURDTGGAGZMWHQ-RQJHMYQMSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
199.2
MW (Da)
-0.10
ALogP
3
HBA
3
HBD
100.6
PSA (Ų)
0.54
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 7.54
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate receptor ionotropic, kainate 1 CHEMBL1918 | Ki | 7.54 | 7.54 | 28.9 | 1 |
| Glutamate receptor ionotropic, kainate 2 CHEMBL3683 | Ki | 5.84 | 5.84 | 1456.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate receptor ionotropic, kainate 1 | Ki | = | 28.9 | nM | 7.54 | Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 ... | 10821708 |
| Glutamate receptor ionotropic, kainate 2 | Ki | = | 1456.0 | nM | 5.84 | Binding affinity against human ionotropic glutamate receptor ionotropic kainate ... | 10821708 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 10821708 | 10.1021/jm9911682 | Glutamate receptor ionotropic, kainate 1 | 1 |
| 10821708 | 10.1021/jm9911682 | Glutamate receptor ionotropic, kainate 2 | 1 |
| 10821708 | 10.1021/jm9911682 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine