Compound Detail
CHEMBL63417
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Basic Information
| ChEMBL ID | CHEMBL63417 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | PCKHNNAQTBNCBG-ZIAGYGMSSA-N |
2
Targets
4
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
346.3
MW (Da)
3.41
ALogP
2
HBA
1
HBD
46.2
PSA (Ų)
0.91
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 4 meas. best 7.17
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate receptor 4 CHEMBL3190 | EC50 | 7.17 | 6.76 | 68.0 | 3 |
| Glutamate receptor 2 CHEMBL4016 | EC50 | 6.28 | 6.28 | 520.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate receptor 4 | EC50 | = | 68.0 | nM | 7.17 | Potentiation of responses mediated by 100 uM L-glutamate in transfected HEK293 c... | 11985477 |
| Glutamate receptor 4 | EC50 | = | 147.0 | nM | 6.83 | Potentiation of responses mediated by 100 uM L-glutamate in transfected HEK293 c... | 11985477 |
| Glutamate receptor 4 | EC50 | = | 520.0 | nM | 6.28 | Inhibition of GluR4 expressed in HEK293 cells | 20839777 |
| Glutamate receptor 2 | EC50 | = | 520.0 | nM | 6.28 | Agonist activity at GluR2 receptor | 20839777 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11985477 | 10.1021/jm0105474 | Glutamate receptor 4 | 2 |
| 20839777 | 10.1021/jm1000419 | Glutamate receptor 4 | 1 |
| 20839777 | 10.1021/jm1000419 | Glutamate receptor 2 | 1 |
Data from ChEMBL 36 via Core Engine