Compound Detail
CHEMBL64692
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
O=C(c1ccc(OCCN2CCCCC2)cc1)c1c2ccc(O)cc2sc1[C@H]1CC[C@H](O)CC1
Basic Information
| ChEMBL ID | CHEMBL64692 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VSKDFCJBACLKIC-MEMLXQNLSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
479.6
MW (Da)
5.72
ALogP
6
HBA
2
HBD
70.0
PSA (Ų)
0.42
QED
1
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 9.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| MCF7 CHEMBL387 | IC50 | 9.3 | 9.3 | 0.5 | 1 |
| Estrogen receptor CHEMBL2093866 | IC50 | 8.7 | 8.7 | 2.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| MCF7 | IC50 | = | 0.5 | nM | 9.3 | Antiproliferative activity against human MCF7 cells | 22405286 |
| Estrogen receptor | IC50 | = | 2.0 | nM | 8.7 | Antagonism of estrogen action in a mammary tumor cell line was assayed via inhib... | 9003514 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 9003514 | 10.1021/jm9606352 | Rattus norvegicus | 10 |
| - | 10.1016/0960-894X(95)00575-E | Estrogen receptor | 7 |
| 9003514 | 10.1021/jm9606352 | Estrogen receptor | 2 |
| 22405286 | 10.1016/j.ejmech.2012.02.021 | Estrogen receptor | 2 |
| 22405286 | 10.1016/j.ejmech.2012.02.021 | MCF7 | 1 |
Data from ChEMBL 36 via Core Engine