Compound Detail
CHEMBL65896
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Basic Information
| ChEMBL ID | CHEMBL65896 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | OZFLGQHJVWSALN-MRXNPFEDSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
267.4
MW (Da)
3.34
ALogP
2
HBA
1
HBD
21.3
PSA (Ų)
0.92
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 6.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| D(2) dopamine receptor CHEMBL217 | Ki | 6.0 | 5.94 | 1010.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| D(2) dopamine receptor | Ki | = | 1010.0 | nM | 6.0 | Displacement of [3H]raclopride from human dopamine D2A receptors expressed in Lt... | 10465538 |
| D(2) dopamine receptor | Ki | = | 1310.0 | nM | 5.88 | Displacement of [3H]quinpirole from human dopamine D2A receptors expressed in Lt... | 10465538 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 10465538 | 10.1016/s0960-894x(99)00345-5 | D(2) dopamine receptor | 10 |
Data from ChEMBL 36 via Core Engine