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Compound Detail

CHEMBL684

DIETHYLCARBAMAZINE
💊 Approved Drug
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💊 Approved Drug
CCN(CC)C(=O)N1CCN(C)CC1
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL684
Name DIETHYLCARBAMAZINE
Phase Approved
Structure Type MOL
InChI Key RCKMWOKWVGPNJF-UHFFFAOYSA-N
Therapeutic ✓ Yes

Known Names

Camin Diethylcarbamazine Dietilcarbamazina
0
Targets
0
Activities
0
Assay Types
0
PK Parameters
20
Publications
3
Known Names
4
Indications

Molecular Properties

199.3
MW (Da)
0.70
ALogP
2
HBA
0
HBD
26.8
PSA (Ų)
0.65
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
First Approval 1950
Availability Discontinued
Chirality Achiral

Routes of Administration

Oral

Flags

Natural Product

Extended Properties

Molecular Formula C10H21N3O
MW 199.30
Aromatic Rings 0
Heavy Atoms 14
NP-Likeness -1.64

Indications

Helminthiasis Elephantiasis, Filarial Loiasis Infections

ATC Classification

P02CB02
diethylcarbamazine
Level 1: ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS
Level 2: ANTHELMINTICS

Literature References

PubMed DOI Target Context # Activities
15646539 10.1016/s0399-8320(04)95062-2 Unchecked 11
3543360 10.1021/jm00157a032 Mastomys natalensis 10
15646539 10.1016/s0399-8320(04)95062-2 NON-PROTEIN TARGET 8
25768703 10.1016/j.ejmech.2015.02.043 Brugia malayi 7
22284816 10.1016/j.bmcl.2012.01.009 Brugia malayi 5
903919 10.1021/jm00220a020 Litomosoides carinii 5
3543360 10.1021/jm00157a032 Rattus norvegicus 4
15582408 10.1016/j.bmcl.2004.10.046 Unchecked 4
22348826 10.1016/j.ejmech.2012.01.057 Brugia malayi 4
3906129 10.1021/jm00149a036 Rattus norvegicus 3
- 10.1007/s00044-010-9331-4 Acanthocheilonema viteae 3
3681893 10.1021/jm00395a010 NON-PROTEIN TARGET 3
37468498 10.1038/s41467-023-40064-9 Thromboxane A2 receptor 2
22194678 10.1371/journal.pcbi.1002310 Hepatotoxicity 2
- 10.6019/CHEMBL4651402 SARS-CoV-2 2
37468498 10.1038/s41467-023-40064-9 Prostaglandin G/H synthase 1 2
6887202 10.1021/jm00363a010 Litomosoides carinii 2
25768703 10.1016/j.ejmech.2015.02.043 Unchecked 2
7031248 10.1021/jm00144a020 Unchecked 2
3681893 10.1021/jm00395a010 Unchecked 2

Data from ChEMBL 36 via Core Engine