Compound Detail
CHEMBL68423
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL68423 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HBXDLZBPKJEWHZ-UHFFFAOYSA-N |
2
Targets
3
Activities
2
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
266.3
MW (Da)
3.31
ALogP
4
HBA
0
HBD
44.2
PSA (Ų)
0.73
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.1
Ki 1 meas. best 7.85
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Platelet-derived growth factor receptor CHEMBL2095189 | Ki | 7.85 | 7.85 | 14.0 | 1 |
| Platelet-derived growth factor receptor CHEMBL2095189 | IC50 | 7.1 | 7.1 | 80.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 6.05 | 6.05 | 900.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Platelet-derived growth factor receptor | Ki | = | 14.0 | nM | 7.85 | Inhibition of PDGF-stimulated autophosphorylation of PDGF-receptor | 8064792 |
| Platelet-derived growth factor receptor | IC50 | = | 80.0 | nM | 7.1 | Inhibition of Platelet-derived growth factor receptor tyrosine kinase | 8064792 |
| Unchecked | IC50 | = | 900.0 | nM | 6.05 | Inhibition of vascular smooth muscle cell proliferation by [3H]thymidine incorpo... | 8064792 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 8064792 | 10.1021/jm00043a002 | Platelet-derived growth factor receptor | 2 |
| 8064792 | 10.1021/jm00043a002 | Unchecked | 2 |
| 8064792 | 10.1021/jm00043a002 | Epidermal growth factor receptor | 1 |
| 8064792 | 10.1021/jm00043a002 | Receptor tyrosine-protein kinase erbB-2 | 1 |
| 8064792 | 10.1021/jm00043a002 | Tyrosine-protein kinase Lck | 1 |
| 8064792 | 10.1021/jm00043a002 | Protein kinase C (PKC) | 1 |
Data from ChEMBL 36 via Core Engine