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Compound Detail

CHEMBL689

MANNITOL
💊 Approved Drug
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💊 Approved Drug
OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL689
Name MANNITOL
Phase Approved
Structure Type MOL
InChI Key FBPFZTCFMRRESA-KVTDHHQDSA-N
Therapeutic ✓ Yes

Known Names

Aridol kit Bronchitol Cordycepic acid Crystalline mannitol extra-fine Crystalline mannitol fine Crystalline mannitol standard D-(-)-mannitol D-mannitol Diosmol E-421 E421 INS NO.421 +18 more
0
Targets
2
Activities
1
Assay Types
3
PK Parameters
20
Publications
30
Known Names
20
Indications
1
Mechanisms

Molecular Properties

182.2
MW (Da)
-3.59
ALogP
6
HBA
6
HBD
121.4
PSA (Ų)
0.26
QED
1
Ro5 Violations
5
Rot. Bonds

Drug Information

Molecule Type Small molecule
First Approval 1982
Availability Prescription
Chirality Single Enantiomer

Routes of Administration

Parenteral Topical

Flags

Natural Product

Extended Properties

Molecular Formula C6H14O6
MW 182.17
Aromatic Rings 0
Heavy Atoms 12
NP-Likeness 1.14

Mechanism of Action

Mechanism Action Type Target Direct Efficacy
Unknown - - ✓ ✓

Indications

Acute Kidney Injury Asthma, Exercise-Induced Brain Edema Constipation Cystic Fibrosis Brain Diseases Brain Injuries Bronchiectasis Ciguatera Poisoning Coronary Disease Fetal Hypoxia Hernias, Diaphragmatic, Congenital Kidney Neoplasms Malaria Respiratory Sounds Shock, Septic Hearing Loss Hypotension Opioid-Related Disorders Osteoarthritis, Knee

ATC Classification

A06AD16
mannitol
Level 1: ALIMENTARY TRACT AND METABOLISM
Level 2: DRUGS FOR CONSTIPATION
B05BC01
mannitol
Level 1: BLOOD AND BLOOD FORMING ORGANS
Level 2: BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS
B05CX04
mannitol
Level 1: BLOOD AND BLOOD FORMING ORGANS
Level 2: BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS
R05CB16
mannitol
Level 1: RESPIRATORY SYSTEM
Level 2: COUGH AND COLD PREPARATIONS
V04CX04
mannitol
Level 1: VARIOUS
Level 2: DIAGNOSTIC AGENTS

Activity Summary

IC50 2 meas.

Pharmacokinetic Data

Parameter Value Units Species
F 18.0 % Homo sapiens
F 16.0 % Homo sapiens
F 26.0 % Homo sapiens

Literature References

PubMed DOI Target Context # Activities
- 10.6019/CHEMBL3885881 Rattus norvegicus 202
22194678 10.1371/journal.pcbi.1002310 Hepatotoxicity 14
22355035 10.1124/dmd.111.041616 Broad substrate specificity ATP-binding cassette transporter ABCG2 12
11602674 - ATP-dependent translocase ABCB1 11
15081037 10.1016/j.bmcl.2004.01.107 ADMET 10
3351858 10.1021/jm00399a019 Rattus norvegicus 7
15081037 10.1016/j.bmcl.2004.01.107 Homo sapiens 7
22355035 10.1124/dmd.111.041616 ADMET 6
15658873 10.1021/jm049711o ADMET 5
29929882 10.1016/j.bmcl.2018.06.009 ADMET 5
19762238 10.1016/j.bmcl.2009.08.071 Caco-2 3
11384238 10.1021/jm001101a Homo sapiens 3
20014752 10.1021/tx900326k Hepatotoxicity 3
37468498 10.1038/s41467-023-40064-9 Muscarinic acetylcholine receptor M1 3
37468498 10.1038/s41467-023-40064-9 Alpha-1A adrenergic receptor 3
15149639 10.1016/j.bmcl.2004.04.035 Spinacia oleracea 3
11784135 10.1021/jm010152k ADMET 3
10841786 10.1021/jm991156g Liposome 2
18063225 10.1016/j.ejmech.2007.10.029 NON-PROTEIN TARGET 2
15844957 10.1021/np0495985 NON-PROTEIN TARGET 2

Data from ChEMBL 36 via Core Engine