Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL695

TRIMETHADIONE
💊 Approved Drug
Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
💊 Approved Drug
CN1C(=O)OC(C)(C)C1=O
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL695
Name TRIMETHADIONE
Phase Approved
Structure Type MOL
InChI Key IRYJRGCIQBGHIV-UHFFFAOYSA-N
Therapeutic ✓ Yes

Known Names

A 2297 Absentol Epidione J2.519D Minoaleviatin NSC-15799 NSC-169503 Tridione Tridone Trimetadiona Trimethadione Trimethadionum
0
Targets
0
Activities
0
Assay Types
4
PK Parameters
20
Publications
12
Known Names
1
Indications
1
Mechanisms

Molecular Properties

143.1
MW (Da)
0.37
ALogP
3
HBA
0
HBD
46.6
PSA (Ų)
0.49
QED
0
Ro5 Violations
0
Rot. Bonds

Drug Information

Molecule Type Small molecule
First Approval 1946
Availability Discontinued
Chirality Achiral

Routes of Administration

Oral

Flags

Natural Product

Extended Properties

Molecular Formula C6H9NO3
MW 143.14
Aromatic Rings 0
Heavy Atoms 10
NP-Likeness 0.31

Mechanism of Action

Mechanism Action Type Target Direct Efficacy
Voltage-gated T-type calcium channel blocker BLOCKER Voltage-gated T-type calcium channel ✓ ✓

Indications

Epilepsy

ATC Classification

N03AC02
trimethadione
Level 1: NERVOUS SYSTEM
Level 2: ANTIEPILEPTICS

Pharmacokinetic Data

Parameter Value Units Species
CL 0.7 mL.min-1.kg-1 Homo sapiens
CL 1.6 mL.min-1.kg-1 Macaca
CL 2.9 mL.min-1.kg-1 Canis lupus familiaris
CL 5.7 mL.min-1.kg-1 Rattus norvegicus

Literature References

PubMed DOI Target Context # Activities
- 10.6019/CHEMBL3885861 Rattus norvegicus 1383
- 10.6019/CHEMBL3885881 Rattus norvegicus 283
16472241 10.2174/1570163043334794 Hepatotoxicity 18
15646539 10.1016/s0399-8320(04)95062-2 Unchecked 11
15920768 10.1002/jps.20373 ADMET 8
15646539 10.1016/s0399-8320(04)95062-2 NON-PROTEIN TARGET 8
17747 10.1021/jm00216a012 Mus musculus 6
28817930 10.1021/acs.jmedchem.7b00606 Carbonic anhydrase 2 5
37468498 10.1038/s41467-023-40064-9 Cannabinoid receptor 1 3
7932556 10.1021/jm00046a013 Mus musculus 3
- 10.1016/0960-894X(96)00220-X ADMET 3
20014752 10.1021/tx900326k Hepatotoxicity 3
2846842 10.1021/jm00119a025 Mus musculus 3
18479918 10.1016/j.bmcl.2008.04.067 Mus musculus 2
23321016 10.1016/j.bmc.2012.12.033 Mus musculus 2
26948801 10.1016/j.drudis.2016.02.015 Homo sapiens 2
- 10.6019/CHEMBL4651402 SARS-CoV-2 2
- 10.6019/CHEMBL4495565 SARS-CoV-2 2
- 10.1016/0960-894X(96)00220-X Mus musculus 2
- 10.6019/CHEMBL4808148 Histone deacetylase 6 2

Data from ChEMBL 36 via Core Engine