Compound Detail
CHEMBL696
ETHOSUXIMIDE 💊 Approved Drug
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💊 Approved Drug
Basic Information
| ChEMBL ID | CHEMBL696 |
| Name | ETHOSUXIMIDE |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | HAPOVYFOVVWLRS-UHFFFAOYSA-N |
| Therapeutic | ✓ Yes |
0
Targets
1
Activities
1
Assay Types
5
PK Parameters
20
Publications
12
Known Names
8
Indications
1
Mechanisms
Molecular Properties
141.2
MW (Da)
0.45
ALogP
2
HBA
1
HBD
46.2
PSA (Ų)
0.54
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1960 |
| Availability | Prescription |
| Chirality | Racemic |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Voltage-gated T-type calcium channel blocker | BLOCKER | Voltage-gated T-type calcium channel | ✓ | ✓ |
Indications
Epilepsy Epilepsy, Absence Irritable Bowel Syndrome Seizures Complex Regional Pain Syndromes Neuralgia Migraine Disorders Depressive Disorder
ATC Classification
N03AD01
ethosuximide
Level 1: NERVOUS SYSTEM
Level 2: ANTIEPILEPTICS
N03AD51
ethosuximide, combinations
Level 1: NERVOUS SYSTEM
Level 2: ANTIEPILEPTICS
Activity Summary
IC50 1 meas.
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 0.15 | mL.min-1.kg-1 | Homo sapiens |
| CL | 0.33 | mL.min-1.kg-1 | Macaca |
| CL | 0.42 | mL.min-1.kg-1 | Canis lupus familiaris |
| CL | 3.1 | mL.min-1.kg-1 | Rattus norvegicus |
| F | 80.0 | % | Homo sapiens |
Literature References
Data from ChEMBL 36 via Core Engine