Compound Detail
CHEMBL6993
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Basic Information
| ChEMBL ID | CHEMBL6993 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SDTFBAXSPXZDKC-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
161.2
MW (Da)
0.51
ALogP
3
HBA
2
HBD
71.8
PSA (Ų)
0.59
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 1 meas. best 5.68
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Queuine tRNA-ribosyltransferase catalytic subunit 1 CHEMBL6004 | Ki | 5.68 | 5.68 | 2100.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Queuine tRNA-ribosyltransferase catalytic subunit 1 | Ki | = | 2100.0 | nM | 5.68 | Inhibition of TGT | 18457385 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 6864738 | 10.1021/jm00361a012 | Dihydrofolate reductase | 1 |
| 18457385 | 10.1021/jm8000373 | Queuine tRNA-ribosyltransferase catalytic subunit 1 | 1 |
| 1271401 | 10.1021/jm00227a006 | Dihydrofolate reductase | 1 |
| 25466178 | 10.1016/j.bmcl.2014.11.004 | Nucleic Acid | 1 |
Data from ChEMBL 36 via Core Engine